Afatinib dimaleate

Catalog No.: A14985
EGFR inhibitor
Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.
Grouped product items
Product Name Price Stock Qty
Afatinib dimaleate 25mg
$75.00
In stock
Afatinib dimaleate 50mg
$110.00
In stock
Afatinib dimaleate 100mg
$150.00
In stock
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Biological Activity
Discription Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.
Targets
Target Value
Product Information
Catalog Num A14985
Formula C32H33ClFN5O11
Molecular Weight 718.08
CAS Number 850140-73-7
SMILES CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
Synonyms BIBW 2992MA2, BIBW-2992, BIBW2992, BIBW 2992, Afatinib
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 87 mg/mL (121.3 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+30% PEG 300+ddH2O 26 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.93 mL 69.63 mL 139.26 mL
0.5 mM 2.79 mL 13.93 mL 27.85 mL
1 mM 1.39 mL 6.96 mL 13.93 mL
5 mM 0.28 mL 1.39 mL 2.79 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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