RI-1

Catalog No.: A13187
RAD51 Inhibitor II
RI-1 is a small molecule that inhibits the central recombination protein RAD51. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA.
Grouped product items
Product Name Price Stock Qty
RI-1 5mg
$75.00
In stock
RI-1 10mg
$130.00
In stock
RI-1 25mg
$260.00
In stock
RI-1 50mg
$490.00
In stock
RI-1 10mM * 1mL in DMSO
$83.00
In stock
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Biological Activity
Discription RI-1 is a small molecule that inhibits the central recombination protein RAD51. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA.
Targets
Target Value
Product Information
Catalog Num A13187
Formula C14H11Cl3N2O3
Molecular Weight 361.61
CAS Number 415713-60-9
SMILES C1COCCN1C2=C(C(=O)N(C2=O)C3=CC(=C(C=C3)Cl)Cl)Cl
Synonyms RI1?? RI 1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 48 mg/mL (132.74 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.65 mL 138.27 mL 276.54 mL
0.5 mM 5.53 mL 27.65 mL 55.31 mL
1 mM 2.77 mL 13.83 mL 27.65 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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