Cilomilast (SB-207499)

Catalog No.: A10216
PDE-4 inhibitor
Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD.
Grouped product items
Product Name Price Stock Qty
Cilomilast (SB-207499) 5mg
$75.00
In stock
Cilomilast (SB-207499) 10mg
$138.00
In stock
Cilomilast (SB-207499) 50mg
$420.00
In stock
Cilomilast (SB-207499) 100mg
$680.00
In stock
Cilomilast (SB-207499) 10mM * 1mL in DMSO
$111.00
In stock
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Biological Activity
Discription Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD.
Targets
Target Value
Product Information
Catalog Num A10216
Formula C20H25NO4
Molecular Weight 343.4
CAS Number 153259-65-5
SMILES COC1=C(C=C(C=C1)C2(CCC(CC2)C(=O)O)C#N)OC3CCCC3
Synonyms Ariflo
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 64 mg/mL (186.36 mM)
Water Insoluble
Ethanol 47 mg/mL (136.85 mM)
In vivo 5% DMSO+95% Corn oil 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.12 mL 145.6 mL 291.21 mL
0.5 mM 5.82 mL 29.12 mL 58.24 mL
1 mM 2.91 mL 14.56 mL 29.12 mL
5 mM 0.58 mL 2.91 mL 5.82 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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