Sivelestat

Catalog No.: A14184
Neutrophil elastase inhibitor
Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase).
Grouped product items
Product Name Price Stock Qty
Sivelestat 10mg
$65.00
In stock
Sivelestat 25mg
$130.00
In stock
Sivelestat 50mg
$240.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase).
Targets
Target Value
Product Information
Catalog Num A14184
Formula C20H22N2O7S
Molecular Weight 434.46
CAS Number 127373-66-4
SMILES CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O
Synonyms Elastase Inhibitor IV
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 76 mg/mL (174.92 mM)
Water Insoluble
Ethanol 76 mg/mL (174.92 mM)
In vivo 5% DMSO+40% PEG 300+5% Tween 80+ddH2O 21 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.02 mL 115.09 mL 230.17 mL
0.5 mM 4.6 mL 23.02 mL 46.03 mL
1 mM 2.3 mL 11.51 mL 23.02 mL
5 mM 0.46 mL 2.3 mL 4.6 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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