TAK-285
Important Notice: For research use only. We do not sell to patients.
Not your Region? View all Distributors
Important Notice: For research use only. We do not sell to patients.
Not your Region? View all Distributors
Discription | TAK-285 is an investigational HER2/EGFR inhibitor that penetrates the CNS in Rats with an Intact Blood Brain Barrier (BBB). TAK-285 has inhibitory activity against HER2 and EGFR kinases with IC50 values for HER2 and EGFR of 17 nmol/L (95% CI 12-24) and 23 nmol/L (95% CI 18-30), respectively.[1] | ||
---|---|---|---|
Targets |
|
Catalog Num | A11236 |
---|---|
Formula | C26H25ClF3N5O3 |
Molecular Weight | 548 |
CAS Number | 871026-44-7 |
SMILES | CC(C)(CC(=O)NCCN1C=CC2=C1C(=NC=N2)NC3=CC(=C(C=C3)OC4=CC=CC(=C4)C(F)(F)F)Cl)O |
Synonyms | TAK285 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 97 mg/mL (177.02 mM) | |
Water | Insoluble | ||
Ethanol | 48 mg/mL (87.59 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 18.25 mL | 91.24 mL | 182.48 mL |
0.5 mM | 3.65 mL | 18.25 mL | 36.5 mL |
1 mM | 1.82 mL | 9.12 mL | 18.25 mL |
5 mM | 0.36 mL | 1.82 mL | 3.65 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2