XL-228
Important Notice: For research use only. We do not sell to patients.
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Important Notice: For research use only. We do not sell to patients.
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Discription | XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases. | ||
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Targets |
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Catalog Num | A13069 |
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Formula | C22H31N9O |
Molecular Weight | 437.5 |
CAS Number | 898280-07-4 |
SMILES | CC(C)C1=NOC(=C1)CNC2=NC(=CC(=N2)NC3=NNC(=C3)C4CC4)N5CCN(CC5)C |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 79 mg/mL (180.55 mM) | |
Water | Insoluble | ||
Ethanol | 27 mg/mL (61.7 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 22.86 mL | 114.29 mL | 228.57 mL |
0.5 mM | 4.57 mL | 22.86 mL | 45.71 mL |
1 mM | 2.29 mL | 11.43 mL | 22.86 mL |
5 mM | 0.46 mL | 2.29 mL | 4.57 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2