HIF-2a Translation Inhibitor

Catalog No.: A16181
HIF-2a translation inhibitor
HIF-2a translation inhibitor (IC50 value 5 uM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element).
Grouped product items
Product Name Price Stock Qty
HIF-2a Translation Inhibitor 76 5mg
$70.00
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HIF-2a Translation Inhibitor 76 10mg
$120.00
In stock
HIF-2a Translation Inhibitor 76 50mg
$480.00
In stock
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Biological Activity
Discription HIF-2a translation inhibitor (IC50 value 5 uM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element).
Product Information
Catalog Num A16181
Formula C9H9N3O4S2
Molecular Weight 287.31
CAS Number 882268-69-1
SMILES COC(=O)C1=C(C=CS1)NN=C(C#N)S(=O)(=O)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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