MK-0752

Catalog No.: A11194
Gamma-secretase inhibitor
MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.
Grouped product items
Product Name Price Stock Qty
MK-0752 5mg
$150.00
In stock
MK-0752 10mg
$250.00
In stock
MK-0752 50mg
$550.00
In stock
MK-0752 100mg
$900.00
In stock
MK-0752 10mM * 1mL in DMSO
$192.00
In stock
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Biological Activity
Discription MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.
Product Information
Catalog Num A11194
Formula C21H21ClF2O4S
Molecular Weight 442.9
CAS Number 471905-41-6
SMILES C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
Synonyms MK0752
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 85 mg/mL (191.91 mM)
Water Insoluble
Ethanol 43 mg/mL (97.08 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.58 mL 112.89 mL 225.78 mL
0.5 mM 4.52 mL 22.58 mL 45.16 mL
1 mM 2.26 mL 11.29 mL 22.58 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
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