TAK-632

Catalog No.: A13323
pan-RAF inhibitor
TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.
Grouped product items
Product Name Price Stock Qty
TAK-632 10mg
$39.00
In stock
TAK-632 25mg
$69.00
In stock
TAK-632 50mg
$115.00
In stock
TAK-632 10mM * 1mL in DMSO
$80.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's TAK-632 has been cited by 1 publications
  • Yosi Shamay, .et al. , Nat Mater, 2018, Apr; 17(4): 361-368 PMID: 29403054
  • Biological Activity
    Discription TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.
    Targets
    Target Value
    Product Information
    Catalog Num A13323
    Formula C27H18F4N4O3S
    Molecular Weight 554.51
    CAS Number 1228591-30-7
    SMILES C1CC1C(=O)NC2=NC3=C(S2)C(=C(C=C3)OC4=CC(=C(C=C4)F)NC(=O)CC5=CC(=CC=C5)C(F)(F)F)C#N
    Synonyms TAK 632; TAK632
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 99 mg/mL (178.53 mM)
    Water Insoluble
    Ethanol 2 mg/mL (3.6 mM)
    In vivo 2% DMSO+98% PEG 300 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18.03 mL 90.17 mL 180.34 mL
    0.5 mM 3.61 mL 18.03 mL 36.07 mL
    1 mM 1.8 mL 9.02 mL 18.03 mL
    5 mM 0.36 mL 1.8 mL 3.61 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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