EPZ004777

Catalog No.: A12983
DOT1L inhibitor
EPZ004777 is a potent, selective inhibitor of DOT1L. EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes.
Grouped product items
Product Name Price Stock Qty
EPZ004777 5mg
$110.00
In stock
EPZ004777 10mg
$190.00
In stock
EPZ004777 25mg
$290.00
In stock
EPZ004777 50mg
$550.00
In stock
EPZ004777 10mM * 1mL in DMSO
$131.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription EPZ004777 is a potent, selective inhibitor of DOT1L. EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes.
Targets
Target Value
Product Information
Catalog Num A12983
Formula C28H41N7O4
Molecular Weight 539.67
CAS Number 1338466-77-5
SMILES CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C3N=CN=C4N)O)O
Synonyms EPZ 004777, EPZ-004777
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 95 mg/mL (176.03 mM)
Water Insoluble
Ethanol 95 mg/mL (176.03 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.53 mL 92.65 mL 185.3 mL
0.5 mM 3.71 mL 18.53 mL 37.06 mL
1 mM 1.85 mL 9.26 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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