MK-8617

Catalog No.: A12618
pan HIF PHD1-3 inhibitor
MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.
Grouped product items
Product Name Price Stock Qty
MK-8617 5mg
$70.00
In stock
MK-8617 10mg
$100.00
In stock
MK-8617 50mg
$360.00
In stock
MK-8617 100mg
$680.00
In stock
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Adooq Products cited in reputable paper
Biological Activity
Discription MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.
Product Information
Catalog Num A12618
Formula C24H21N5O4
Molecular Weight 443.45
CAS Number 1187990-87-9
SMILES O=C(C1=CN=C(C2=NN=CC=C2)N=C1O)NC(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4
Synonyms MK 8617, MK8617
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO Warmed: 17 mg/mL (38.34 mM)
Water Insoluble
Ethanol 1 mg/mL (2.25 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.55 mL 112.75 mL 225.5 mL
0.5 mM 4.51 mL 22.55 mL 45.1 mL
1 mM 2.26 mL 11.28 mL 22.55 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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