MRTX1257

Catalog No.: A17223
KRAS-G12C inhibitor
MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.
Grouped product items
Product Name Price Stock Qty
MRTX1257 5mg
$140.00
In stock
MRTX1257 10mg
$250.00
In stock
MRTX1257 50mg
$900.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

Not your Region? View all Distributors

Adooq Products cited in reputable paper
Biological Activity
Discription MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.
Targets
Target Value
Product Information
Catalog Num A17223
Formula C33H39N7O2
Molecular Weight 565.722
CAS Number 2206736-04-9
SMILES N#CC[C@@H]1N(C(C=C)=O)CCN(C2=C3C(CN(C4=C5C(C)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1
Synonyms MRTX-1257; MRTX 1257;
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 89 mg/mL (157.32 mM)
Water Insoluble
Ethanol 27 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.68 mL 88.38 mL 176.77 mL
0.5 mM 3.54 mL 17.68 mL 35.35 mL
1 mM 1.77 mL 8.84 mL 17.68 mL
5 mM 0.35 mL 1.77 mL 3.54 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

    V1

    C2

    V2

  • Calculator Reset
Keywords: buy MRTX1257 | MRTX1257 Supplier | purchase MRTX1257 | MRTX1257 cost | MRTX1257 manufacturer | order MRTX1257 | MRTX1257 distributor | buy 2206736-04-9 | 2206736-04-9 Supplier | purchase 2206736-04-9 | 2206736-04-9 cost | 2206736-04-9 manufacturer | order 2206736-04-9 | 2206736-04-9 distributor