Avitinib (AC0010)

Catalog No.: A16826
irreversible EGFR inhibitor
Avitinib (AC0010) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM). It has comparable anti-tumor activity and tolerated toxicity.
Grouped product items
Product Name Price Stock Qty
Avitinib (AC0010) 5mg
$70.00
In stock
Avitinib (AC0010) 10mg
$120.00
In stock
Avitinib (AC0010) 50mg
$400.00
In stock
Avitinib (AC0010) 100mg
$600.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription Avitinib (AC0010) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM). It has comparable anti-tumor activity and tolerated toxicity.
Product Information
Catalog Num A16826
Formula C26H26FN7O2
Molecular Weight 487.53
CAS Number 1557267-42-1
SMILES C=CC(NC1=CC=CC(OC2=C3C(NC=C3)=NC(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)=N2)=C1)=O
Synonyms AC-0010, AC 0010, Abivertinib
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 90 mg/mL (184.6 mM)
Water Insoluble
Ethanol 90 mg/mL (184.6 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.51 mL 102.56 mL 205.12 mL
0.5 mM 4.1 mL 20.51 mL 41.02 mL
1 mM 2.05 mL 10.26 mL 20.51 mL
5 mM 0.41 mL 2.05 mL 4.1 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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