Avitinib (AC0010)
Important Notice: For research use only. We do not sell to patients.
Not your Region? View all Distributors
Important Notice: For research use only. We do not sell to patients.
Not your Region? View all Distributors
Discription | Avitinib (AC0010) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM). It has comparable anti-tumor activity and tolerated toxicity. |
---|
Catalog Num | A16826 |
---|---|
Formula | C26H26FN7O2 |
Molecular Weight | 487.53 |
CAS Number | 1557267-42-1 |
SMILES | C=CC(NC1=CC=CC(OC2=C3C(NC=C3)=NC(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)=N2)=C1)=O |
Synonyms | AC-0010, AC 0010, Abivertinib |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 90 mg/mL (184.6 mM) | |
Water | Insoluble | ||
Ethanol | 90 mg/mL (184.6 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 20.51 mL | 102.56 mL | 205.12 mL |
0.5 mM | 4.1 mL | 20.51 mL | 41.02 mL |
1 mM | 2.05 mL | 10.26 mL | 20.51 mL |
5 mM | 0.41 mL | 2.05 mL | 4.1 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2