Apoptozole

Catalog No.: A21177
Hsc70 and Hsp70 inhibitor
Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14?μM, respectively, and can induce apoptosis.
Grouped product items
Product Name Price Stock Qty
Apoptozole 5mg
$50.00
In stock
Apoptozole 10mg
$85.00
In stock
Apoptozole 50mg
$253.00
In stock
Apoptozole 100mg
$506.00
In stock
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Biological Activity
Discription Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14?μM, respectively, and can induce apoptosis.
Targets
Target Value
Product Information
Catalog Num A21177
Formula C33H25F6N3O3
Molecular Weight 625.56
CAS Number 1054543-47-3
SMILES NC(C(C=C1)=CC=C1CN2C(C3=CC=C(OC)C=C3)=C(C4=CC=C(OC)C=C4)N=C2C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O
Synonyms Apoptosis Activator VII
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 96 mg/mL (153.46 mM)
Water Insoluble
Ethanol 24 mg/mL (38.36 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.99 mL 79.93 mL 159.86 mL
0.5 mM 3.2 mL 15.99 mL 31.97 mL
1 mM 1.6 mL 7.99 mL 15.99 mL
5 mM 0.32 mL 1.6 mL 3.2 mL
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