Canertinib dihydrochloride

Catalog No.: A11344
EGFR inhibitor
Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM.
Grouped product items
Product Name Price Stock Qty
Canertinib dihydrochloride 50mg
$72.00
In stock
Canertinib dihydrochloride 100mg
$124.00
In stock
Canertinib dihydrochloride 500mg
$368.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM.
Targets
Target Value
Product Information
Catalog Num A11344
Formula C24H27Cl3FN5O3
Molecular Weight 558.86
CAS Number 289499-45-2
SMILES C=CC(NC1=CC2=C(N=CN=C2C=C1OCCCN3CCOCC3)NC4=CC=C(C(Cl)=C4)F)=O.[H]Cl.[H]Cl
Synonyms CI-1033 dihydrochloride; PD-183805 dihydrochloride
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 88 mg/mL (157.46 mM)
Water 18 mg/mL (32.2 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.89 mL 89.47 mL 178.94 mL
0.5 mM 3.58 mL 17.89 mL 35.79 mL
1 mM 1.79 mL 8.95 mL 17.89 mL
5 mM 0.36 mL 1.79 mL 3.58 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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