Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

Catalog No.: A10194
Topoisomerase inhibitor

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

Grouped product items
Product Name Price Stock Qty
Cerubidine 10mg
$60.00
In stock
Cerubidine 25mg
$100.00
In stock
Cerubidine 50mg
$160.00
In stock
Cerubidine 100mg
$260.00
In stock
Cerubidine 10mM * 1mL in DMSO
$93.00
In stock
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Important Notice: For research use only. We do not sell to patients.

Prop65 Warning  WARNING: Attention California Residents: This product can expose you to chemicals including Cerubidine (Daunorubicin HCl, Rubidomycin HCl) , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov

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Adooq Products cited in reputable paper
Biological Activity
Discription

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

Targets
Target Value
Product Information
Catalog Num A10194
Formula C27H29NO10.HCl
Molecular Weight 564
CAS Number 23541-50-6
SMILES C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 93 mg/mL (164.9 mM)
Water 93 mg/mL (164.9 mM)
Ethanol Insoluble
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.73 mL 88.65 mL 177.3 mL
0.5 mM 3.55 mL 17.73 mL 35.46 mL
1 mM 1.77 mL 8.87 mL 17.73 mL
5 mM 0.35 mL 1.77 mL 3.55 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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