FzM1.8
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Important Notice: For research use only. We do not sell to patients.
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Discription | FzM1.8 is an allosteric agonist of the Frizzled receptor FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K. |
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Catalog Num | A18760 |
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Formula | C18H14N2O4 |
Molecular Weight | 322.32 |
CAS Number | 2204290-85-5 |
SMILES | O=C(O)C1=CC(NC(NC2=CC=C3C=CC=CC3=C2)=O)=CC(O)=C1 |
Synonyms | FzM1.8; FzM-1.8; FzM 1.8 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2