KPT-6566

Catalog No.: A19126
prolyl isomerase PIN1 inhibitor
KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640?nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity.
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KPT-6566 1mg
KPT-6566 5mg
KPT-6566 10mg
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Biological Activity
Discription KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640?nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity.
Product Information
Catalog Num A19126
Formula C22H21NO5S2
Molecular Weight 443.54
CAS Number 881487-77-0
SMILES O=C(O)CSC(C1=O)=C/C(C2=C1C=CC=C2)=N\S(=O)(C3=CC=C(C(C)(C)C)C=C3)=O
Synonyms KPT 6566; KPT6566
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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