LY2857785

Catalog No.: A15823
CDK9 inhibitor
LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines.
Grouped product items
Product Name Price Stock Qty
LY2857785 5mg
$240.00
In stock
LY2857785 10mg
$390.00
In stock
LY2857785 25mg
$800.00
In stock
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Biological Activity
Discription LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines.
Targets
Target Value
Product Information
Catalog Num A15823
Formula C26H36N6O
Molecular Weight 448.6
CAS Number 1619903-54-6
SMILES CC(C)C1=C2C=C(C=CC2=NN1C)C3=NC(=NC=C3)NC4CCC(CC4)NC5CCOCC5
Synonyms LY-2857785, LY 2857785
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 22 mg/mL (49.04 mM)
Water Insoluble
Ethanol 40 mg/mL (89.16 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.29 mL 111.46 mL 222.92 mL
0.5 mM 4.46 mL 22.29 mL 44.58 mL
1 mM 2.23 mL 11.15 mL 22.29 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
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