S3I-201 (NSC 74859)

S3I-201 (NSC 74859) is a novel inhibitor of Stat3 that inhibits Stat3, Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ?? 33 μM) and Stat3-dependent transcriptional activities.
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Product Name Price Stock Qty
S3I-201 5mg
$40.00
In stock
S3I-201 10mg
$70.00
In stock
S3I-201 50mg
$175.00
In stock
S3I-201 100mg
$330.00
In stock
S3I-201 (NSC 74859) 10mM * 1mL in DMSO
$60.00
In stock
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Adooq Products cited in reputable paper
Adooq's S3I-201 (NSC 74859) has been cited by 4 publications
  • Bae WJ, .et al. , J Exp Clin Cancer Res, 2019, 38:484 PMID: 31805999
  • Ethan L. Morgan, .et al. , PLoS Pathog, 2018, Apr; 14(4): e1006975 PMID: 29630659
  • Nishimura K, .et al. , Biochem Biophys Res Commun, 2018, Jan 1;495(1):1317-1321 PMID: 29191652
  • Soleimani AH, .et al. , Drug Deliv Transl Res, 2017, Aug;7(4):571-581 PMID: 28290050
  • Biological Activity
    Discription S3I-201 (NSC 74859) is a novel inhibitor of Stat3 that inhibits Stat3, Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ?? 33 μM) and Stat3-dependent transcriptional activities.
    Targets
    Target Value
    Product Information
    Catalog Num A10817
    Formula C16H15NO7S
    Molecular Weight 365.4
    CAS Number 501919-59-1
    SMILES CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O
    Synonyms S3I201, NSC74859 , NSC-74859
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 66 mg/mL (180.64 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+corn oil 2 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 27.37 mL 136.84 mL 273.67 mL
    0.5 mM 5.47 mL 27.37 mL 54.73 mL
    1 mM 2.74 mL 13.68 mL 27.37 mL
    5 mM 0.55 mL 2.74 mL 5.47 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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