SAR405

Catalog No.: A21345
PI3KC3 isoform Vps34 inhibitor
SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PI3KC3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM).
Grouped product items
Product Name Price Stock Qty
SAR405 2mg
$81.00
In stock
SAR405 5mg
$162.00
In stock
SAR405 10mg
$315.00
In stock
SAR405 50mg
$927.00
In stock
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Biological Activity
Discription SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PI3KC3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM).
Targets
Target Value
Product Information
Catalog Num A21345
Formula C19H21ClF3N5O2
Molecular Weight 443.85
CAS Number 1523406-39-4
SMILES O=C1N(C2=NC(N3[C@H](C)COCC3)=C1)CC[C@@H](C(F)(F)F)N2CC4=CC(Cl)=CN=C4
Synonyms SAR 405, SAR-405
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO Warmed: 76 mg/mL (171.22 mM)
Water Insoluble
Ethanol 76 mg/mL (171.22 mM)
In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.53 mL 112.65 mL 225.3 mL
0.5 mM 4.51 mL 22.53 mL 45.06 mL
1 mM 2.25 mL 11.27 mL 22.53 mL
5 mM 0.45 mL 2.25 mL 4.51 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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