Simvastatin

Catalog No.: A10845
HMG-CoA reductase inhibitor
Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
Grouped product items
Product Name Price Stock Qty
Simvastatin 50mg
$63.00
In stock
Simvastatin 100mg
$109.00
In stock
Simvastatin 500mg
$322.00
In stock
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Biological Activity
Discription Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
Product Information
Catalog Num A10845
Formula C25H38O5
Molecular Weight 418.57
CAS Number 79902-63-9
SMILES CCC(C)(C)C(O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(O3)=O)[C@@]12[H])=O
Synonyms MK 733, MK-733, MK733
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 71 mg/mL (169.62 mM)
Water Insoluble
Ethanol 71 mg/mL (169.62 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween80+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.89 mL 119.45 mL 238.91 mL
0.5 mM 4.78 mL 23.89 mL 47.78 mL
1 mM 2.39 mL 11.95 mL 23.89 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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