Motesanib (AMG706)

Motesanib (AMG706) is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC?? values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit).
Grouped product items
Product Name Price Stock Qty
Motesanib (AMG706) 5mg
$40.00
In stock
Motesanib (AMG706) 10mg
$50.00
In stock
Motesanib (AMG706) 25mg
$90.00
In stock
Motesanib (AMG706) 50mg
$160.00
In stock
Motesanib (AMG706) 10mM * 1mL in DMSO
$50.00
In stock
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Adooq Products cited in reputable paper
Adooq's Motesanib (AMG706) has been cited by 1 publications
  • Ayaka Kojima, .et al. , Xenobiotica, 2022, Jul;52(7):669-675 PMID: 36251932
  • Biological Activity
    Discription Motesanib (AMG706) is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC?? values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit).
    Targets
    Target Value
    Product Information
    Catalog Num A11496
    Formula C22H23N5O
    Molecular Weight 373.45
    CAS Number 453562-69-1
    SMILES CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
    Synonyms AMG 706, AMG-706
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 68 mg/mL (182.09 mM)
    Water Insoluble
    Ethanol 7 mg/mL (18.74 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 26.78 mL 133.89 mL 267.77 mL
    0.5 mM 5.36 mL 26.78 mL 53.55 mL
    1 mM 2.68 mL 13.39 mL 26.78 mL
    5 mM 0.54 mL 2.68 mL 5.36 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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