Necrostatin-1

Catalog No.: A11973
RIPK1 inhibitor
Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).
Grouped product items
Product Name Price Stock Qty
Necrostatin-1 10mg
$50.00
In stock
Necrostatin-1 25mg
$90.00
In stock
Necrostatin-1 50mg
$150.00
In stock
Necrostatin-1 10mM * 1mL in DMSO
$50.00
In stock
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Biological Activity
Discription Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).
Targets
Target Value
Product Information
Catalog Num A11973
Formula C13H13N3OS
Molecular Weight 259.33
CAS Number 4311-88-0
SMILES CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO Warmed: 43 mg/mL (165.81 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+45% PEG 300+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.56 mL 192.8 mL 385.61 mL
0.5 mM 7.71 mL 38.56 mL 77.12 mL
1 mM 3.86 mL 19.28 mL 38.56 mL
5 mM 0.77 mL 3.86 mL 7.71 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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