AKT inhibitor VIII (AKTI-1/2)

AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays).
Grouped product items
Product Name Price Stock Qty
AKT inhibitor VIII 5mg
$90.00
In stock
AKT inhibitor VIII 10mg
$140.00
In stock
AKT inhibitor VIII 25mg
$300.00
In stock
AKT inhibitor VIII 50mg
$486.00
In stock
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Adooq Products cited in reputable paper
Adooq's AKT inhibitor VIII (AKTI-1/2) has been cited by 2 publications
  • Bjune K, .et al. , PLoS One, 2019, Jun 19;14(6):e0218537 PMID: 31216345
  • Hoshiba T, .et al. , Biochim Biophys Acta, 2016, Nov;1863(11):2749-2757 PMID: 27558478
  • Biological Activity
    Discription AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays).
    Targets
    Target Value
    Product Information
    Catalog Num A11286
    Formula C34H29N7O
    Molecular Weight 551.6
    CAS Number 612847-09-3
    SMILES C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 19 mg/mL (34.44 mM)
    Water Insoluble
    Ethanol Insoluble
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18.13 mL 90.65 mL 181.29 mL
    0.5 mM 3.63 mL 18.13 mL 36.26 mL
    1 mM 1.81 mL 9.06 mL 18.13 mL
    5 mM 0.36 mL 1.81 mL 3.63 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

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