Brigatinib (AP26113)

Catalog No.: A13450
ALK Inhibitor
Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.
Grouped product items
Product Name Price Stock Qty
Brigatinib 5mg
$45.00
In stock
Brigatinib 10mg
$65.00
In stock
Brigatinib 25mg
$120.00
In stock
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Biological Activity
Discription Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.
Product Information
Catalog Num A13450
Formula C29H39ClN7O2P
Molecular Weight 584.09
CAS Number 1197953-54-0
SMILES CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)NC5=CC=CC=C5P(=O)(C)C)Cl)OC
Synonyms AP-26113, AP 26113, AP26113
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO Warmed: 1 mg/mL (1.71 mM)
Water Insoluble
Ethanol Warmed: 39 mg/mL (66.76 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.12 mL 85.6 mL 171.21 mL
0.5 mM 3.42 mL 17.12 mL 34.24 mL
1 mM 1.71 mL 8.56 mL 17.12 mL
5 mM 0.34 mL 1.71 mL 3.42 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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