CBL-0137

Catalog No.: A16836
p53 activator / NF-κB inhibitor
CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).
Grouped product items
Product Name Price Stock Qty
CBL-0137 5mg
$150.00
In stock
CBL-0137 10mg
$250.00
In stock
CBL-0137 50mg
$980.00
In stock
CBL-0137 100mg
$1,600.00
In stock
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Biological Activity
Discription CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).
Targets
Target Value
Product Information
Catalog Num A16836
Formula C21H24N2O2.HCl
Molecular Weight 372.89
CAS Number 1197397-89-9
SMILES CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C.Cl
Synonyms CBL0137, CBL 0137, Curaxin 137, Curaxin137, Curaxin-137, CBLC137, CBLC 137, CBLC-137
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 35 mg/mL (93.86 mM)
Water 22 mg/mL (59 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.82 mL 134.09 mL 268.18 mL
0.5 mM 5.36 mL 26.82 mL 53.64 mL
1 mM 2.68 mL 13.41 mL 26.82 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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