GNE 9605

Catalog No.: A14149
LRRK2 inhibitor
GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively.
Grouped product items
Product Name Price Stock Qty
GNE 9605 5mg
$99.00
In stock
GNE 9605 10mg
$168.00
In stock
GNE 9605 25mg
$297.00
In stock
GNE 9605 10mM * 1mL in DMSO
$167.00
In stock
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Adooq Products cited in reputable paper
Adooq's GNE 9605 has been cited by 1 publications
  • Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138
  • Biological Activity
    Discription GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively.
    Targets
    Target Value
    Product Information
    Catalog Num A14149
    Formula C17H20ClF4N7O
    Molecular Weight 449.83
    CAS Number 1536200-31-3
    SMILES CNC1=NC(=NC=C1C(F)(F)F)NC2=C(N(N=C2)[C@H]3CCN(C[C@@H]3F)C4COC4)Cl
    Synonyms GNE-9605,GNE9605
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 84 mg/mL (186.73 mM)
    Water Insoluble
    Ethanol Warmed: 11 mg/mL (24.45 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.23 mL 111.15 mL 222.31 mL
    0.5 mM 4.45 mL 22.23 mL 44.46 mL
    1 mM 2.22 mL 11.12 mL 22.23 mL
    5 mM 0.44 mL 2.22 mL 4.45 mL
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    This equation is commonly abbreviated as: C1V1 = C2V2

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