RS-127445 is a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 1000x selectivity over the closely related 5-HT2A and 5-HT2C receptors.
RS-127445 is a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 1000x selectivity over the closely related 5-HT2A and 5-HT2C receptors.
Targets
Target
Value
Product Information
Catalog Num
A11165
Formula
C17H16FN3
Molecular Weight
281.33
CAS Number
199864-87-4
SMILES
CC(C)C1=NC(=NC(=C1)C2=CC=C(C3=CC=CC=C32)F)N
Synonyms
RS127445, MT 500, RS127,445
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro
DMSO
54 mg/mL (191.94 mM)
Water
Insoluble
Ethanol
8 mg/mL (28.43 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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