Monomethyl auristatin E

Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.
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Product Name Price Stock Qty
Monomethyl auristatin E 5mg
$120.00
In stock
Monomethyl auristatin E 10mg
$180.00
In stock
Monomethyl auristatin E 25mg
$280.00
In stock
Monomethyl auristatin E 50mg
$480.00
In stock
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Adooq Products cited in reputable paper
Adooq's Monomethyl auristatin E has been cited by 1 publications
  • Sochaj-Gregorczyk AM, .et al. , J Immunother, 2016, Jul-Aug;39(6):223-32 PMID: 27227324
  • Biological Activity
    Discription Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.
    Targets
    Target Value
    Product Information
    Catalog Num A12954
    Formula C39H67N5O7
    Molecular Weight 717.98
    CAS Number 474645-27-7
    SMILES CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC
    Synonyms Monomethylauristatin E, MMAE
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 93 mg/mL (129.52 mM)
    Water Insoluble
    Ethanol 93 mg/mL (129.52 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 13.93 mL 69.64 mL 139.28 mL
    0.5 mM 2.79 mL 13.93 mL 27.86 mL
    1 mM 1.39 mL 6.96 mL 13.93 mL
    5 mM 0.28 mL 1.39 mL 2.79 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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