Netupitant

Catalog No.: A14428
NK1 receptor antagonist
Netupitant is a selective neurokinin 1 (NK1) receptor antagonist. It competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV).
Grouped product items
Product Name Price Stock Qty
Netupitant 5mg
$40.00
In stock
Netupitant 10mg
$70.00
In stock
Netupitant 25mg
$150.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription Netupitant is a selective neurokinin 1 (NK1) receptor antagonist. It competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV).
Targets
Target Value
Product Information
Catalog Num A14428
Formula C30H32F6N4O
Molecular Weight 578.59
CAS Number 290297-26-6
SMILES CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C
Synonyms D05152, AG-E-94200
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 2 mg/mL (3.45 mM)
Water Insoluble
Ethanol 85 mg/mL (146.91 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.28 mL 86.42 mL 172.83 mL
0.5 mM 3.46 mL 17.28 mL 34.57 mL
1 mM 1.73 mL 8.64 mL 17.28 mL
5 mM 0.35 mL 1.73 mL 3.46 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

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This equation is commonly abbreviated as: C1V1 = C2V2

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