A1874

Catalog No.: A18735
BRD4-degrading PROTAC
A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation.
Grouped product items
Product Name Price Stock Qty
A1874 1mg
$180.00
In stock
A1874 5mg
$620.00
In stock
A1874 10mg
$880.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Biological Activity
Discription A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation.
Targets
Target Value
Product Information
Catalog Num A18735
Formula C58H62Cl3F2N9O7S
Molecular Weight 1173.6
CAS Number 2064292-12-0
SMILES CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)NCCOCCOCCOCCNC(=O)C4=CC(=C(C=C4)NC(=O)[C@H]5[C@@H]([C@@]([C@@H](N5)CC(C)(C)C)(C#N)C6=C(C=C(C=C6)Cl)F)C7=C(C(=CC=C7)Cl)F)OC)C8=CC=C(C=C8)Cl)C
Synonyms A1874, A-1874
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 92 mg/mL (78.38 mM)
Water Insoluble
Ethanol 92 mg/mL (78.38 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.52 mL 42.6 mL 85.21 mL
0.5 mM 1.7 mL 8.52 mL 17.04 mL
1 mM 0.85 mL 4.26 mL 8.52 mL
5 mM 0.17 mL 0.85 mL 1.7 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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