AX-024 hydrochloride

Catalog No.: A18332
TNF receptor inhibitor
AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases.
Grouped product items
Product Name Price Stock Qty
AX-024 hydrochloride 2mg
$105.00
In stock
AX-024 hydrochloride 5mg
$165.00
In stock
AX-024 hydrochloride 10mg
$275.00
In stock
AX-024 hydrochloride 50mg
$1,050.00
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Biological Activity
Discription AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases.
Targets
Target Value
Product Information
Catalog Num A18332
Formula C21H23ClFNO2
Molecular Weight 375.8684
CAS Number 1704801-24-0
SMILES COC1=CC(C(C2=CC=C(F)C=C2)=C(CN3CCCC3)CO4)=C4C=C1.[H]Cl
Synonyms AX-024; AX 024; AX024 HCl; AX-024 hydrochloride
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 64 mg/mL (170.27 mM)
Water 3 mg/mL (7.98 mM)
Ethanol 15 mg/mL (39.91 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.61 mL 133.03 mL 266.05 mL
0.5 mM 5.32 mL 26.61 mL 53.21 mL
1 mM 2.66 mL 13.3 mL 26.61 mL
5 mM 0.53 mL 2.66 mL 5.32 mL
Useful Calculator

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