Afatinib

Catalog No.: A18014
EGFR inhibitor
Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.
Grouped product items
Product Name Price Stock Qty
Afatinib 10mg
$54.00
In stock
Afatinib 25mg
$108.00
In stock
Afatinib 50mg
$186.00
In stock
Afatinib 100mg
$318.00
In stock
Bulk Size
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Biological Activity
Discription Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.
Targets
Target Value
Product Information
Catalog Num A18014
Formula C24H25ClFN5O3
Molecular Weight 485.94
CAS Number 850140-72-6
SMILES O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[C@@H]4COCC4)/C=C/CN(C)C
Synonyms BIBW 2992, BIBW-2992, BIBW2992
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 90 mg/mL (185.21 mM)
Water Insoluble
Ethanol 14 mg/mL (28.8 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.58 mL 102.89 mL 205.79 mL
0.5 mM 4.12 mL 20.58 mL 41.16 mL
1 mM 2.06 mL 10.29 mL 20.58 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

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    C2

    V2

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