ARRY-380 (Irbinitinib)

Catalog No.: A16413
HER2 inhibitor
ARRY-380 is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity.
Grouped product items
Product Name Price Stock Qty
ARRY-380 5mg
$41.00
In stock
ARRY-380 10mg
$70.00
In stock
ARRY-380 50mg
$205.00
In stock
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Biological Activity
Discription ARRY-380 is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity.
Targets
Target Value
Product Information
Catalog Num A16413
Formula C26H24N8O2
Molecular Weight 480.52
CAS Number 937263-43-9
SMILES CC1=C(C=CC(=C1)NC2=NC=NC3=C2C=C(C=C3)NC4=NC(CO4)(C)C)OC5=CC6=NC=NN6C=C5
Synonyms Tucatinib, ONT-380, Irbinitinib
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 87 mg/mL (181.05 mM)
Water Insoluble
Ethanol 14 mg/mL (29.13 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.81 mL 104.05 mL 208.11 mL
0.5 mM 4.16 mL 20.81 mL 41.62 mL
1 mM 2.08 mL 10.41 mL 20.81 mL
5 mM 0.42 mL 2.08 mL 4.16 mL
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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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