CHIR-99021 monohydrochloride

Catalog No.: A21430
GSK-3α/β inhibitor
CHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.
Grouped product items
Product Name Price Stock Qty
CHIR-99021 monohydrochloride 5mg
$72.00
In stock
CHIR-99021 monohydrochloride 10mg
$124.00
In stock
CHIR-99021 monohydrochloride 50mg
$368.00
In stock
CHIR-99021 monohydrochloride 100mg
$736.00
In stock
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Biological Activity
Discription CHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.
Targets
Target Value
Product Information
Catalog Num A21430
Formula C22H19Cl3N8
Molecular Weight 501.8
CAS Number 1797989-42-4
SMILES N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl
Synonyms CHIR99021, CHIR 99021, CT99021 monohydrochloride, CT 99021, CT-99021
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 89 mg/mL (177.36 mM)
Water Insoluble
Ethanol 2 mg/mL (3.98 mM)
In vivo 5% DMSO+30% PEG 300+ddH2O 22 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.93 mL 99.64 mL 199.28 mL
0.5 mM 3.99 mL 19.93 mL 39.86 mL
1 mM 1.99 mL 9.96 mL 19.93 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

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This equation is commonly abbreviated as: C1V1 = C2V2

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