Danusertib (PHA-739358)

Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2
Grouped product items
Product Name Price Stock Qty
Danusertib 5mg
$100.00
In stock
Danusertib 10mg
$180.00
In stock
Danusertib 25mg
$350.00
In stock
Danusertib 50mg
$560.00
In stock
Danusertib (PHA-739358) 10mM * 1mL in DMSO
$120.00
In stock
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Adooq Products cited in reputable paper
Adooq's Danusertib (PHA-739358) has been cited by 1 publications
  • Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138
  • Biological Activity
    Discription Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2
    Targets
    Target Value
    Product Information
    Catalog Num A10715
    Formula C26H30N6O3
    Molecular Weight 474.6
    CAS Number 827318-97-8
    SMILES CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)[C@@H](C5=CC=CC=C5)OC
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 93 mg/mL (195.97 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.07 mL 105.35 mL 210.7 mL
    0.5 mM 4.21 mL 21.07 mL 42.14 mL
    1 mM 2.11 mL 10.54 mL 21.07 mL
    5 mM 0.42 mL 2.11 mL 4.21 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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