FG-2216

Catalog No.: A15530
HIF-prolyl hydroxylase inhibitor
FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo,
Grouped product items
Product Name Price Stock Qty
FG-2216 5mg
$55.00
In stock
FG-2216 10mg
$90.00
In stock
FG-2216 25mg
$180.00
In stock
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Biological Activity
Discription FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo,
Targets
Target Value
Product Information
Catalog Num A15530
Formula C12H9ClN2O4
Molecular Weight 280.66
CAS Number 223387-75-5
SMILES C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O
Synonyms YM-311
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 48 mg/mL (171.02 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+40% PEG 300+2% Twenn 80+ddH2O 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.63 mL 178.15 mL 356.3 mL
0.5 mM 7.13 mL 35.63 mL 71.26 mL
1 mM 3.56 mL 17.82 mL 35.63 mL
5 mM 0.71 mL 3.56 mL 7.13 mL
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