Signaling Pathway
PTC-209 HBr is the hydrobromide salt of PTC-209. PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of cancer-initiating cells (CICs).
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| Discription | PTC-209 HBr is the hydrobromide salt of PTC-209. PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of cancer-initiating cells (CICs). |
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| Catalog Num | A14280 |
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| Formula | C17H13Br2N5OS.HBr |
| Molecular Weight | 576.1 |
| CAS Number | 1217022-63-3 |
| SMILES | CC1=C(N2C=CC=NC2=N1)C3=CSC(=N3)NC4=C(C=C(C=C4Br)OC)Br.Br |
| Synonyms | PTX209 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | Warmed: 99 mg/mL (171.84 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+35% PEG 300+2% Tween 80+ddH2O | 6 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.36 mL | 86.79 mL | 173.58 mL |
| 0.5 mM | 3.47 mL | 17.36 mL | 34.72 mL |
| 1 mM | 1.74 mL | 8.68 mL | 17.36 mL |
| 5 mM | 0.35 mL | 1.74 mL | 3.47 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
