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TAS4464

Catalog No.: A18485
NAE inhibitor
TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM.
TAS4464
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Product Name Price Stock Qty
TAS4464 5mg
$350.00
In stock
TAS4464 10mg
$650.00
In stock
TAS4464 50mg
$2,000.00
In stock
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Biological Activity
Discription TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM.
Product Information
Catalog Num A18485
Formula C21H23FN6O6S
Molecular Weight 506.5
CAS Number 1848959-10-3
SMILES NC1=C2C(N([C@H]3[C@@H]([C@@H]([C@@H](CNS(=O)(N)=O)O3)O)O)C=C2C#CC4=C(F)C=CC=C4OCC)=NC=N1
Synonyms TAS4464; TAS-4464; TAS 4464
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro DMSO 90 mg/mL (177.68 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.74 mL 98.72 mL 197.43 mL
0.5 mM 3.95 mL 19.74 mL 39.49 mL
1 mM 1.97 mL 9.87 mL 19.74 mL
5 mM 0.39 mL 1.97 mL 3.95 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Proteases > NEDD8-activating Enzyme (NAE)
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