MD2-TLR4-IN-1
Important Notice: For research use only. We do not sell to patients.
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Important Notice: For research use only. We do not sell to patients.
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Discription | MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. |
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Catalog Num | A18452 |
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Formula | C22H14Cl2N4O |
Molecular Weight | 421.28 |
CAS Number | 2249801-12-3 |
SMILES | ClC1=C(C(NC2=CC(C(C3=CC=C(NC=C4)C4=C3)=NN5)=C5C=C2)=O)C(Cl)=CC=C1 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 81 mg/mL (192.27 mM) | |
Water | Insoluble | ||
Ethanol | 5 mg/mL | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 23.74 mL | 118.69 mL | 237.37 mL |
0.5 mM | 4.75 mL | 23.74 mL | 47.47 mL |
1 mM | 2.37 mL | 11.87 mL | 23.74 mL |
5 mM | 0.47 mL | 2.37 mL | 4.75 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2