ML221

Catalog No.: A19446
APJ functional antagonist
ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
Grouped product items
Product Name Price Stock Qty
ML221 5mg
$65.00
In stock
ML221 10mg
$110.00
In stock
ML221 50mg
$330.00
In stock
ML221 100mg
$560.00
In stock
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Biological Activity
Discription ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
Product Information
Catalog Num A19446
Formula C17H11N3O6S
Molecular Weight 385.35
CAS Number 877636-42-5
SMILES O=C1C=C(CSC2=NC=CC=N2)OC=C1OC(C3=CC=C([N+]([O-])=O)C=C3)=O
Synonyms ML 221, ML-221
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 8 mg/mL (20.76 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.95 mL 129.75 mL 259.5 mL
0.5 mM 5.19 mL 25.95 mL 51.9 mL
1 mM 2.6 mL 12.98 mL 25.95 mL
5 mM 0.52 mL 2.6 mL 5.19 mL
Useful Calculator

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