MRK-016

Catalog No.: A12046
GABAA α5 receptor agonist
MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77?and 1.4?nM for human?GABAA?α1β3γ2, GABAA?α2β3γ2, GABAA?α3β3γ2, and GABAA?α5β3γ2, respectively; MRK-016 also readily penetrates the CNS.
Grouped product items
Product Name Price Stock Qty
MRK-016 5mg
$90.00
In stock
MRK-016 10mg
$155.00
In stock
MRK-016 50mg
$460.00
In stock
MRK-016 100mg
$920.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77?and 1.4?nM for human?GABAA?α1β3γ2, GABAA?α2β3γ2, GABAA?α3β3γ2, and GABAA?α5β3γ2, respectively; MRK-016 also readily penetrates the CNS.
Product Information
Catalog Num A12046
Formula C17H20N8O2
Molecular Weight 368.39
CAS Number 342652-67-9
SMILES CN1N=CN=C1COC2=NN3C(C4=NOC(C)=C4)=NN=CC3=C2C(C)(C)C
Synonyms MRK 016, MRK016
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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