Gefitinib-based PROTAC 3

Catalog No.: A19093
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.
Grouped product items
Product Name Price Stock Qty
Gefitinib-based PROTAC 3 5mg
$270.00
In stock
Gefitinib-based PROTAC 3 10mg
$465.00
In stock
Gefitinib-based PROTAC 3 50mg
$1,380.00
In stock
Gefitinib-based PROTAC 3 100mg
$2,760.00
In stock
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Biological Activity
Discription Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.
Targets
Target Value
Product Information
Catalog Num A19093
Formula C47H57ClFN7O8S
Molecular Weight 934.51
CAS Number 2230821-27-7
SMILES O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 92 mg/mL (98.44 mM)
Water Insoluble
Ethanol 92 mg/mL (98.44 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.7 mL 53.5 mL 107.01 mL
0.5 mM 2.14 mL 10.7 mL 21.4 mL
1 mM 1.07 mL 5.35 mL 10.7 mL
5 mM 0.21 mL 1.07 mL 2.14 mL
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