KPT 9274 (ATG-019)

Catalog No.: A15506

PAK4/NAMPT Inhibitor

KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.
Grouped product items
Product Name Price Stock Qty
KPT-9274 2mg
$100.00
In stock
KPT-9274 5mg
$200.00
In stock
KPT-9274 10mg
$320.00
In stock
KPT-9274 25mg
$650.00
In stock
KPT-9274 100mg
$1,400.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.
Product Information
Catalog Num A15506
Formula C35H29F3N4O3
Molecular Weight 610.63
CAS Number 1643913-93-2
SMILES FC1=CC=C(C2=CC(C3=CC=C(C(N4CCC(F)(F)CC4)=O)C=C3)=CC5=C2OC(C/N=C(O)/C([H])=C([H])/C6=NC(N)=CC=C6)=C5)C=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 85 mg/mL (139.2 mM)
Water Insoluble
Ethanol 85 mg/mL (139.2 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.38 mL 81.88 mL 163.77 mL
0.5 mM 3.28 mL 16.38 mL 32.75 mL
1 mM 1.64 mL 8.19 mL 16.38 mL
5 mM 0.33 mL 1.64 mL 3.28 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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