Lifitegrast

Catalog No.: A17299
LFA-1 antagonist
Lifitegrast (SAR 1118) is an integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist; inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM.
Grouped product items
Product Name Price Stock Qty
Lifitegrast 10mg
$59.00
In stock
Lifitegrast 50mg
$177.00
In stock
Lifitegrast 100mg
$295.00
In stock
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Biological Activity
Discription Lifitegrast (SAR 1118) is an integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist; inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM.
Targets
Target Value
Product Information
Catalog Num A17299
Formula C29H24Cl2N2O7S
Molecular Weight 615.478
CAS Number 1025967-78-5
SMILES O=C(O)[C@@H](NC(C1=C(Cl)C2=C(CN(C(C3=CC=C4C=COC4=C3)=O)CC2)C=C1Cl)=O)CC5=CC=CC(S(=O)(C)=O)=C5
Synonyms SAR-1118; SAR 1118; SAR1118; Lifitegrast, brand name: Xiidra.
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 98 mg/mL (159.22 mM)
Water Insoluble
Ethanol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.25 mL 81.24 mL 162.48 mL
0.5 mM 3.25 mL 16.25 mL 32.5 mL
1 mM 1.62 mL 8.12 mL 16.25 mL
5 mM 0.32 mL 1.62 mL 3.25 mL
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