R112

Catalog No.: A14161
Syk inhibitor
R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells and also blocked leukotriene C4 production and all proinflammatory cytokines tested.
Grouped product items
Product Name Price Stock Qty
R112 5mg
$81.00
In stock
R112 10mg
$138.00
In stock
R112 25mg
$243.00
In stock
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Biological Activity
Discription R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells and also blocked leukotriene C4 production and all proinflammatory cytokines tested.
Product Information
Catalog Num A14161
Formula C16H13FN4O2
Molecular Weight 312.3
CAS Number 575474-82-7
SMILES C1=CC(=CC(=C1)O)NC2=NC(=NC=C2F)NC3=CC(=CC=C3)O
Synonyms R 112, R-112
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 61 mg/mL (195.32 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.02 mL 160.1 mL 320.2 mL
0.5 mM 6.4 mL 32.02 mL 64.04 mL
1 mM 3.2 mL 16.01 mL 32.02 mL
5 mM 0.64 mL 3.2 mL 6.4 mL
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