NMS-873

Catalog No.: A12377
p97 inhibitor
NMS-873 is a potent and specific small molecule allosteric inhibitor of the ATPase VCP/p97 (IC50 ~0.03 uM), identified by a high-throughput screening.
Grouped product items
Product Name Price Stock Qty
NMS-873 5mg
$70.00
In stock
NMS-873 10mg
$120.00
In stock
NMS-873 25mg
$250.00
In stock
NMS-873 50mg
$450.00
In stock
NMS-873 10mM * 1mL in DMSO
$75.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's NMS-873 has been cited by 1 publications
  • Yool Lee, .et al. , Sci Adv, 2021, 7
  • Biological Activity
    Discription NMS-873 is a potent and specific small molecule allosteric inhibitor of the ATPase VCP/p97 (IC50 ~0.03 uM), identified by a high-throughput screening.
    Targets
    Target Value
    Product Information
    Catalog Num A12377
    Formula C27H28N4O3S2
    Molecular Weight 520.67
    CAS Number 1418013-75-8
    SMILES CC1=C(C=CC(=C1)OCC2=NN=C(N2C3=CN=CC=C3)SC4CCCC4)C5=CC=C(C=C5)S(=O)(=O)C
    Synonyms NMS873, NMS 873
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 98 mg/mL (188.22 mM)
    Water Insoluble
    Ethanol Insoluble
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.21 mL 96.03 mL 192.06 mL
    0.5 mM 3.84 mL 19.21 mL 38.41 mL
    1 mM 1.92 mL 9.6 mL 19.21 mL
    5 mM 0.38 mL 1.92 mL 3.84 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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