EW-7197 (Vactosertib)

Catalog No.: A14213
ALK4/ALK5 inhibitor
EW-7197 is a highly potent, selective, and orally bioavailable TGF-β I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively
Grouped product items
Product Name Price Stock Qty
EW-7197 (Vactosertib) 5mg
$70.00
In stock
EW-7197 (Vactosertib) 10mg
$110.00
In stock
EW-7197 (Vactosertib) 25mg
$180.00
In stock
EW-7197 (Vactosertib) 10mM * 1mL in DMSO
$114.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's EW-7197 (Vactosertib) has been cited by 2 publications
  • Bordignon P, .et al. , Cell Rep, 2019, Aug 27;28(9):2358-2372 PMID: 31461652
  • Morita T, .et al. , Mol Cancer Res, 2018, May;16(5):880-893 PMID: 29330296
  • Biological Activity
    Discription EW-7197 is a highly potent, selective, and orally bioavailable TGF-β I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively
    Targets
    Target Value
    Product Information
    Catalog Num A14213
    Formula C22H18FN7
    Molecular Weight 399.42
    CAS Number 1352608-82-2
    SMILES CC1=CC=CC(=N1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4
    Synonyms EW7197
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 77 mg/mL (192.77 mM)
    Water Insoluble
    Ethanol 42 mg/mL (105.15 mM)
    In vivo 1%cmc-na 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 25.04 mL 125.18 mL 250.36 mL
    0.5 mM 5.01 mL 25.04 mL 50.07 mL
    1 mM 2.5 mL 12.52 mL 25.04 mL
    5 mM 0.5 mL 2.5 mL 5.01 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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