Hesperadin

Catalog No.: A10448
Aurora B Kinase inhibitor
Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo.
Grouped product items
Product Name Price Stock Qty
Hesperadin 5mg
$54.00
In stock
Hesperadin 10mg
$92.00
In stock
Hesperadin 50mg
$270.00
In stock
Hesperadin 100mg
$918.00
In stock
Hesperadin 10mM * 1mL in DMSO
$152.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's Hesperadin has been cited by 1 publications
  • Wenbin Ji, .et al. , PLoS One, 2016, 11(4): e0153518 PMID: 27082996
  • Biological Activity
    Discription Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo.
    Targets
    Target Value
    Product Information
    Catalog Num A10448
    Formula C29H32N4O3S
    Molecular Weight 516.7
    CAS Number 422513-13-1
    SMILES CCS(=O)(=O)NC1=CC\2=C(C=C1)NC(=O)/C2=C(/C3=CC=CC=C3)\NC4=CC=C(C=C4)CN5CCCCC5
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 100 mg/mL (193.55 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+40%PEG300+5% tween80+50% H2O 2.3 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.35 mL 96.77 mL 193.54 mL
    0.5 mM 3.87 mL 19.35 mL 38.71 mL
    1 mM 1.94 mL 9.68 mL 19.35 mL
    5 mM 0.39 mL 1.94 mL 3.87 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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